Pluraflavins, Potent Antitumor Antibiotics from Saccharothrix sp. DSM 12931

LÁSZLÓ VÉRTESY; FRANCIS P. BARBONE; ELIZABETH CASHMEN; HEINRICH DECKER; KLAUS EHRLICH; BIRGIT JORDAN; MARTIN KNAUF; DIETMAR SCHUMMER; MARIAN P. SEGETH; JOACHIM WINK; GERHARD SEIBERT

doi:10.7164/antibiotics.54.718

Pluraflavins, Potent Antitumor Antibiotics from Saccharothrix sp. DSM 12931

LÁSZLÓ VÉRTESY, FRANCIS P. BARBONE, ELIZABETH CASHMEN, HEINRICH DECKER, KLAUS EHRLICH, BIRGIT JORDAN, MARTIN KNAUF, DIETMAR SCHUMMER, MARIAN P. SEGETH, JOACHIM WINK, GERHARD SEIBERT

著者情報

ジャーナルフリー

2001 年 54 巻 9 号 p. 718-729

DOI https://doi.org/10.7164/antibiotics.54.718

詳細

抄録

The new pluramycin-type antibiotics pluraflavin A, C₄₃H₅₄N₂O₁₄, pluraflavin B, C₄₃H₅₆N₂O₁₅, and pluraflavin E, C₃₆H₄₁NO₁₄ were isolated from cultures of the Saccharothrix species DSM 12931. The structures of the novel compounds were elucidated with the aid of 2D NMR and mass spectrometric investigations. The characteristic structural element of pluraflavins A and B is an additional 4-epi-vancosamine unit at position 13 of the anthraquinone-γ-pyrone ring system. Pluraflavin E has a carboxyl group in this position. Pluraflavin A has a reactive dimethyl epoxide side chain at position 2 of the anthraquinone-γ-pyrone aglycon, which may explain the high activity of the antibiotic. The outstanding biological characteristic of pluraflavin A is its powerful, organ-dependent cytostatic action: the IC₅₀ in the colon carcinoma proliferation assay is in the subnanomolar range.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）