CJ-21, 164, a New D-Glucose-6-phosphate Phosphohydrolase Inhibitor Produced by a Fungus Chloridium sp.

YOON-JEONG KIM; HIROYUKI NISHIDA; CHANG-HONG PANG; TOSHIYUKI SAITO; SHINICHI SAKEMI; HIROKO TONAI-KACHI; NOBUJI YOSHIKAWA; MARIA A. VANVOLKENBURG; JANICE C. PARKER; YASUHIRO KOJIMA

doi:10.7164/antibiotics.55.121

CJ-21, 164, a New D-Glucose-6-phosphate Phosphohydrolase Inhibitor Produced by a Fungus Chloridium sp.

YOON-JEONG KIM, HIROYUKI NISHIDA, CHANG-HONG PANG, TOSHIYUKI SAITO, SHINICHI SAKEMI, HIROKO TONAI-KACHI, NOBUJI YOSHIKAWA, MARIA A. VANVOLKENBURG, JANICE C. PARKER, YASUHIRO KOJIMA

Author information

YOON-JEONG KIM
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
HIROYUKI NISHIDA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
CHANG-HONG PANG
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
TOSHIYUKI SAITO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
SHINICHI SAKEMI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
HIROKO TONAI-KACHI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
NOBUJI YOSHIKAWA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
MARIA A. VANVOLKENBURG
PGRD, Groton Laboratories, Pfizer Inc.
JANICE C. PARKER
PGRD, Groton Laboratories, Pfizer Inc.
YASUHIRO KOJIMA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

JOURNAL FREE ACCESS

2002 Volume 55 Issue 2 Pages 121-127

DOI https://doi.org/10.7164/antibiotics.55.121

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Abstract

A new D-glucose-6-phosphate phosphohydrolase (G6Pase) inhibitor, CJ-21, 164 (I) was isolated from the fermentation broth of the fungus Chloridium sp. CL48903. The structure was elucidated to be a novel tetramer of the salicylic acid derivatives by spectroscopic analyses. Compound I inhibited G6Pase in rat liver microsomes with an IC₅₀ of 1.6μM. Glucose output from hepatocytes isolated from rat liver was inhibited when I was present in the incubation medium, consistent with the role of I as a G6Pase inhibitor.

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