Milbemycin α17 and Related Compounds Synthesized from Milbemycin A4
Synthetic Procedure and Acaricidal Activities
2003 年 56 巻 10 号 p. 848-855
詳細
2003 年 56 巻 10 号 p. 848-855
Milbemycin α17, a 14-demethyl congener of milbemycin A4, has been reported as a natural product. In this paper, we report the successful development of a chemical derivation method to synthesize milbemycin α17 from milbemycin A4, as well as our use of a similar method to prepare 24-demethylmilbemycin A4 from the same precursor. The acaricidal activities of these compounds were assessed against the organophosphorus-sensitive two-spotted spider mites (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
