YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties

KOJI NAGAI; KAZUMA KAMIGIRI; NAKAKO ARAO; KEN-ICHI SUZUMURA; YASUHIRO KAWANO; MASAKAZU YAMAOKA; HUIPING ZHANG; MASATO WATANABE; KENICHI SUZUKI

doi:10.7164/antibiotics.56.123

YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties

KOJI NAGAI, KAZUMA KAMIGIRI, NAKAKO ARAO, KEN-ICHI SUZUMURA, YASUHIRO KAWANO, MASAKAZU YAMAOKA, HUIPING ZHANG, MASATO WATANABE, KENICHI SUZUKI

著者情報

KOJI NAGAI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
KAZUMA KAMIGIRI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
NAKAKO ARAO
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
KEN-ICHI SUZUMURA
Analysis & Metabolism Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
YASUHIRO KAWANO
Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology
MASAKAZU YAMAOKA
Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology
HUIPING ZHANG
Chemistry of Natural Drugs, School of Pharmacy, Fudan University
MASATO WATANABE
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
KENICHI SUZUKI
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

ジャーナルフリー

2003 年 56 巻 2 号 p. 123-128

DOI https://doi.org/10.7164/antibiotics.56.123

詳細

抄録

Novel antibiotics, YM-266183 (1) and YM-266184 (2), were found in the culture broth of Bacillus cereus QN03323 which was isolated from the marine sponge Halichondria japonica. The structures of both antibiotics were determined by several spectroscopic experiments as new thiopeptide compounds. They exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains, whereas they were inactive against Gramnegative bacteria.

責任著者(Corresponding author)

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