Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp. II. Isolation, Characterization, and Structure Determination

JOHN E. LEET; WENYING LI; HELEN A. AX; JAMES A. MATSON; STELLA HUANG; RON HUANG; JOSEPH L. CANTONE; DIETER DREXLER; RICHARD A. DALTERIO; KIN S. LAM

doi:10.7164/antibiotics.56.232

Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp.

II. Isolation, Characterization, and Structure Determination

JOHN E. LEET, WENYING LI, HELEN A. AX, JAMES A. MATSON, STELLA HUANG, RON HUANG, JOSEPH L. CANTONE, DIETER DREXLER, RICHARD A. DALTERIO, KIN S. LAM

Author information

JOHN E. LEET
Bristol-Myers Squibb Pharmaceutical Research Institute
WENYING LI
Bristol-Myers Squibb Pharmaceutical Research Institute
HELEN A. AX
Bristol-Myers Squibb Pharmaceutical Research Institute
JAMES A. MATSON
Bristol-Myers Squibb Pharmaceutical Research Institute
STELLA HUANG
Bristol-Myers Squibb Pharmaceutical Research Institute
RON HUANG
Bristol-Myers Squibb Pharmaceutical Research Institute
JOSEPH L. CANTONE
Bristol-Myers Squibb Pharmaceutical Research Institute
DIETER DREXLER
Bristol-Myers Squibb Pharmaceutical Research Institute
RICHARD A. DALTERIO
Bristol-Myers Squibb Pharmaceutical Research Institute
KIN S. LAM
Bristol-Myers Squibb Pharmaceutical Research Institute

JOURNAL FREE ACCESS

2003 Volume 56 Issue 3 Pages 232-242

DOI https://doi.org/10.7164/antibiotics.56.232

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Abstract

A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSⁿ) methods, and share structural similarities to glycothiohexide-α (4).

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