New Monordens Produced by Amidepsine-producing Fungus Humicola sp. FO-2942

MASAYOSHI ARAI; KAZUNOBU YAMAMOTO; ICHIJI NAMATAME; HIROSHI TOMODA; SATOSHI OMURA

doi:10.7164/antibiotics.56.526

New Monordens Produced by Amidepsine-producing Fungus Humicola sp. FO-2942

MASAYOSHI ARAI, KAZUNOBU YAMAMOTO, ICHIJI NAMATAME, HIROSHI TOMODA, SATOSHI OMURA

著者情報

ジャーナルフリー

2003 年 56 巻 6 号 p. 526-532

DOI https://doi.org/10.7164/antibiotics.56.526

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抄録

Based on UV spectrum-guided purification, new monordens C, D and E, known monordens A (radicicol) and B and 5-O-methylsclerone were isolated from the fermentation broth of amidepsine-producing Humicola sp. FO-2942 by solvent extraction, silica-gel column chromatography, ODS column chromatography and HPLC. All monordens cause the cell cycle arrest at G1 and G2/M phases in Jurkat cells. But among them, monordens A and E show antifungal activity only against Aspergillus niger.

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