DNA-Binding Properties of Cosmomycin D, an Anthracycline with Two Trisaccharide Chains

RENATA L. A. FURLAN; STEPHEN J. WATT; LEANDRO M. GARRIDO; GUSTAVO P. AMARANTE-MENDES; MOHAMMAD NUR-E-ALAM; JURGEN ROHR; ALFREDO BRAÑA; CARMEN MENDEZ; JOSE A. SALAS; MARGARET M. SHEIL; JENNIFER L. BECK; GABRIEL PADILLA

doi:10.7164/antibiotics.57.647

RENATA L. A. FURLAN, STEPHEN J. WATT, LEANDRO M. GARRIDO, GUSTAVO P. AMARANTE-MENDES, MOHAMMAD NUR-E-ALAM, JURGEN ROHR, ALFREDO BRAÑA, CARMEN MENDEZ, JOSE A. SALAS, MARGARET M. SHEIL, JENNIFER L. BECK, GABRIEL PADILLA

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ジャーナルフリー

2004 年 57 巻 10 号 p. 647-654

DOI https://doi.org/10.7164/antibiotics.57.647

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抄録

Cosmomycin D (CosD) is the major constituent fraction isolated from a culture of Streptomyces olindensis ICB20. The ability of this compound to intercalate with double-stranded DNA was studied by gel mobility shift assays and electrospray ionization mass spectrometry (ESI-MS). ESI-MS experiments showed that the complex of CosD with 16-mer double-stranded DNA was at least as stable as a complex of daunorubicin with the same DNA sequence. This is the first study showing DNA binding properties of an anthracycline containing a β-rhodomycinone aglycone chromophore O-linked to two trisaccharide chains.

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