Abstract
AC-PC, 6-(1-aminocyclohexanecarboxamido) penicillanic acid, exhibits antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Minimal inhibitory concentrations against Gram-positive bacteria range from 0.195 to 3.125mcg/ml and against Gram-negative bateria range from 12.5 to 100mcg/ml. Mild penicillin G resistant staphylococci are inhibited in the range of 3.125-50mcg/ml. The antibacterial activity of this penicillin is not greatly influenced by the pH of medium, the inoculum size and presence of horse serum. Susceptibility to AC-PC decreases rapidly in vitro by serial transfer, but resistant degree in terms of concentration become stationary after the 6 th passages through the 15th. AC-PC demonstrates bactericidal and bacteriolytic actions against Staph. aureus and E. coli. The solution of AC-PC at pH 2 is stable at 37°C at least for a period of 5 hours.
