Abstract
The therapeutic effectiveness of AC-PC, 6-(1-aminocyclohexanecarboxamide) penicillanic acid, in CF-1/H mice intraperitoneally challenged by penicillin G sensitive as well as resistant strains of Staph. aureus, Strept. pyogenes, E. coli, Pr. vulgaris and K. pneumoniae is determined by single oral, subcutaneous, intravenous or intraperitoneal administration of the antibiotic, immediately after the challenge. The effective dose (ED50) is calculated on the basis of numbers of deaths for 7 days. AC-PC is very effective against Gram-positive bacterial infection. The antibiotic is also effective against Gram-negative bacterial infection.
