Abstract
Eighty patients with severe urinary tract infections were treated with cefazolin (CEZ) and ephaloridine (CER), using a double blind method, and the following results were obtained.
Strains of E.coli isolated from patients were more sensitive to CEZ than to CER.
Disappearance of the organisms in urine of the patients with acute or subacute urinary tract infections was statistically more rapid in the group treated with CEZ than in the group treated with CEK (α=0.01). However, no significant differences were noted between both drugs in clinical effectiveness and relapse rate. The therapeutic effect of CEZ, therefore, proved satisfactory as that of CER.
No adverse reactions were encountered except eruption in each one patient of both groups, who were dropped out in this experiment.
Laboratory examinations were made on peripheral blood figures, liver and renal function before and after therapy, without any abnormalities observed.
