Abstract
In the patients with reduced renal function 0.5g of lividoinycin (LVM) was injected intramuscularly every 12 hours for 3 days, and blood and urine levels were determined many times consecutively.The correlation between the levels and the total renal function was studied in the patients with variously impaired renal function. In one case who undertook the nephrostomy the functions of both kidneys were compared in regard to the levels.
In general, the blood levels 12 hours after the intramuscular injection of 0.5g of LVM were too low to inhibit the growth of urinary pathogens, but, even after 12 hours the urine levels were sufficiently high to inhibit them in many cases (more than 100mcg/ml).
The blood levels determined every 12 hours after consecutive injections had a tendency to rise gradually. This tendency became more obvious in proportion to the reduction of renal function.Urinary recovery of LVM decreased in proportion to the degree of the impairment of the renal function.
