Abstract
The teratogenicity of 3', 4'-dideoxykanamycin B (DKB) was studied using dd strain mice and Donryu strain rats and the following results were obtained:
(1) In mice, 89.7% of mothers died in 400 mg/kg (as base activity) intraperitoneal injection group and 64.1% of mothers in 250 mg/kg intramuscular injection group. In rats, 35.0% of mothers died in 300 mg/kg intramuscular injection group.
(2) In embryonic mortality, no significant difference was observed between the control and medicated group.
(3) In fetal abnormalities in appearance and skeleton, no significant difference was observed between the control and medicated group.
(4) No effect of DKB was observed on birth rate, survival rate, growing body weight and organs of newborns.
(5) No teratogenic effect was observed in mice and rats administered intraperitoneally and intramuscularly with DKB.
