STUDY ON AMPICILLIN AQUEOUS SUSPENSION FOR INTRAMUSCULAR INJECTION. I

COMPARISON WITH SODIUM AMPICILLIN IN BLOOD LEVEL AND TISSUE DISTRIBUTION IN RABBITS

Abstract

Ampicillin trihydrate aqueous suspension (AB-PC Sol), a new ampicillin formulation for intramuscular injection, was studied on its blood level and tissue distribution comparatively with sodium ampicillin solution (AB-PC Na) by using rabbits.
Blood level was tested by cross-over method using three rabbits at 20 mg/kg single dose by intramuscular injection, and tissue distribution after 100 mg/kg administration of each drugs was studied separately.
From the result of both experiments, AB-PC Sol was proved to have significantly longer duration of effective antibiotic level in blood and tissues than AB-PC Na, though higher peak levels of the activity were observed by AB-PC Na.