Abstract
Ampicillin trihydrate aqueous suspension (AB-PC Sol), a new ampicillin formulation for intramuscular injection, was studied on its protective effects against experimental infections with Streptococcus hemolyticus S 23, Proteus morganii strain 0237, Staphylococcus aureus 226 and S. aureus strain 0040 in rats and mice.
Against the infection with S. hemolyticus S 23 in rats, AB-PC Sol proved to be more effective than sodium ampicillin (AB-PC Na). Higher protective effects of AB-PC Sol in comparison with AB-PC Na were observed also against infections with AB-PC resistant strains, P. morganii strain 0237, S. aureus 226 and S. aureus strain 0040 in mice.
