Abstract
The investigation of physico-chemical properties and measurement of blood concentration and amount of excretion into urine in human of OE-7 (main constituent is erythromycin stearate) were perfbrmed as the fundamental studies.The results obtained were as follows;
i) OE-7 is a gastric hard capsule containing enteric coated granules.
ii) The contents of OE-7 capsule (granules) were resistant to acid and was favarable in the enteric solubility.
iii) In comparison with the conventional erythromycin stearate capsule in healthy adults, OE-7 showed a relatively small individual difference in blood concentration after administration.
iv) OE-7 was higher in the mean blood concentration and was superior in the persistence of effective blood concentration compared with the conventional erythromycin stearate capsules.
