Abstract
The excretion of T-1220 in bile was evaluated in 4 patients with biliary tract diseases. The bile was collected for 6 hours after intravenous injection of T-1220. The maximal concentration in bile was 1,600mcg/ml at 0.5-1 hour after administration of 1g of T-1220 to 1 case. In 3 cases treated with 2g, the maximal concentration was 155-1,115mcg/ml at 2-3 hours after administration. Total excretion rates in bile after 0-6 hours were 0.5-7.2%.
T-1220 was applied clinically to 3 patients with biliary tract infections. Clinical results obtained were good in all cases.
No side effect was observed in all cases.
