Abstract
S-6437 is a preparation of sustained release cefalexin consisting of non-enteric coated granules and enteric coated ones and it is reported that the drug shows good effectiveness with b.i.d. regimen.
Various infections in pediatrics were treated with S-6437 and the following results were obtained. Dose used was 40-100 mg/kg/day at 2 divided doses after breakfast and dinner.
1) Twenty patients (87.0%) of the 23 with respiratory tract infections and 3(60.0%) of the 5 with the other infections responded to the drug. Overall effectiveness was 82.1% (23/28 cases).
2) As for side effects, tentative diarrhea was observed in 5 patients (17.2%) of the 29 but no other severe side effects were found.
3) S-6437 is considered to be a drug which overcomes inconvenience of giving regular cefalexin four times a day.
