Abstract
Pharmacokinetic analysis was performed on the results of serum concentration, urinary excretion and distribution following intravenous rapid injection and constant infusion of intravenous preparation of fosfomycin sodium salt (disodium (-)-(1R, 2S)-1, 2-epoxypropylphosphonate). The results were as follows:
1) Pharmacokinetic parameters in the two-compartment open model were derived from the serum concentration data after intravenous rapid injection to the rabbit and the dog. These parameters were in the little range of deviation and had almost the same value at the dose levels from 10mg (acid) /kg to 40 or 80mg (acid) /kg for each animal.
2) The serum concentration and urinary excretion after intravenous rapid injection, constanti nfusion and these repetitive dosing were predicted with the aid of the parameters obtained above. There was good agreement between the predicted values and the observed.
3) The time course of the serum concentration in the man after intravenous constant infusion could be reappeared in the rabbit by changing infusion time adequately.
4) The tissue concentration in the rabbit for the various administration conditions was calculated with the aid of the parameters derived from the distribution data after intravenous rapid injection. The predicted values agreed well with the observed.
5) The tissue concentration after intravenous constant infusion in the administration condition that the dose was equal and the infusion time was a half of the biological half life attained to the same level as those after intravenous rapid injection in the rabbit.
