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Volume 31, Issue 8
Displaying 1-5 of 5 articles from this issue
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KEI-ICHI YAGINUMA, SHINJIRO MURATA, KOSHIRO UMEMURA, NORIKO TOMONO, SH ...1978 Volume 31 Issue 8 Pages 465-473
Published: August 25, 1978
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSPharmacokinetic analysis was performed on the results of serum concentration, urinary excretion and distribution following intravenous rapid injection and constant infusion of intravenous preparation of fosfomycin sodium salt (disodium (-)-(1R, 2S)-1, 2-epoxypropylphosphonate). The results were as follows:
1) Pharmacokinetic parameters in the two-compartment open model were derived from the serum concentration data after intravenous rapid injection to the rabbit and the dog. These parameters were in the little range of deviation and had almost the same value at the dose levels from 10mg (acid) /kg to 40 or 80mg (acid) /kg for each animal.
2) The serum concentration and urinary excretion after intravenous rapid injection, constanti nfusion and these repetitive dosing were predicted with the aid of the parameters obtained above. There was good agreement between the predicted values and the observed.
3) The time course of the serum concentration in the man after intravenous constant infusion could be reappeared in the rabbit by changing infusion time adequately.
4) The tissue concentration in the rabbit for the various administration conditions was calculated with the aid of the parameters derived from the distribution data after intravenous rapid injection. The predicted values agreed well with the observed.
5) The tissue concentration after intravenous constant infusion in the administration condition that the dose was equal and the infusion time was a half of the biological half life attained to the same level as those after intravenous rapid injection in the rabbit.View full abstractDownload PDF (1077K) -
YOICHIRO KAMINAGA, MUNEAKI IZUMI, AKIRA ITO, YUZO WATANABE, HIROSHI SH ...1978 Volume 31 Issue 8 Pages 474-479
Published: August 25, 1978
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
TOMOJI YAMADA, AKIO MARU, TAKAO TAKAMURA, MASAAKI MOTOMURA, TAKEMI NAM ...1978 Volume 31 Issue 8 Pages 480-486
Published: August 25, 1978
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
KUNITOMO WATANABE, IZUMI WATANABE, TAKAYUKI EZAKI, SHUNRO KOBATA, HIRO ...1978 Volume 31 Issue 8 Pages 487-492
Published: August 25, 1978
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThe antimicrobial activity of josamycin I, erythromycin II, midecamycin III, lincomycin IV, clindamycin V, cephalexin VI, cephaloridine VII and cefazolin VIII against anaerobes (20 strains of Bacteroides fragilis, 9 strains of B. distasonis, 9 strains of B. vulgatus, 4 strains of B. thetaiotaomicron, 1 strain of B. praeacutus, 1 strain of Fusobacterium russii, 1 strain of F. nucleatum, 1 strain of F.freundii, 2 strains of F. varium, 1 strain of Eubacterium limosum, 1 strain of Bifidobacterium adolescentis, 1 strain of Clostridium perfringens, 6 strains of Peptococcus variabilis, 4 strains of P. asaccharolyticus, 1 strain of P. aerogenes, 5 Strains'of Peptostreptococcus anaerobius, 4 strains of Peptostreptococcus intermedius and 4 strains of Gafficjia a naerobia) was examined.
The results obtained are mentioned below:
1. The antimicrobial activity against B.fragilis, B.thetaiotaomicron, B.vulgatus and B.distasoniswas superior in the order of V, I, III, II and IV. I was superior in antimicrobial activity to VI, VII and VIII.
2. The antimicrobial activity against P.variabilis was superior in the order of VII, V, I and VIII. The antimicrobial activity against P.asaccharolyticus was superior in the order of V, IV and VII.
3. I and V were most antibacterial against Ps.anaerobius. I and II indicated a high antibacterial activity against Ps.intermedius.
4. IV, VI, VII and VIII were more antibacterial against G. anaerobia than, I; II and III were.
5. I revealed MIC levels of less than 0.78-Eg/ml against B.praeacutus, E.limosum, B.adolescentis, P. aerogenes and C. perfringens, while most of these microbes revealed MIC levels of less than 0.2μg/ml.
6. F. russii was sensitive to 0.2μg/ml of I.F.varium and F.freundii were resistant to 100μg/ml of I, II and III.
7. I showed a good antibacterial activity against 16 anaerobes like B.fragilis, except, for F.varium and F.freundii. Antibacterial activity of I was comparable to that of V.View full abstractDownload PDF (685K) -
ERNST B. CHAINFRS1978 Volume 31 Issue 8 Pages 493-507
Published: August 25, 1978
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSDownload PDF (3257K)
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