Abstract
The antimicrobial activity of josamycin I, erythromycin II, midecamycin III, lincomycin IV, clindamycin V, cephalexin VI, cephaloridine VII and cefazolin VIII against anaerobes (20 strains of Bacteroides fragilis, 9 strains of B. distasonis, 9 strains of B. vulgatus, 4 strains of B. thetaiotaomicron, 1 strain of B. praeacutus, 1 strain of Fusobacterium russii, 1 strain of F. nucleatum, 1 strain of F.freundii, 2 strains of F. varium, 1 strain of Eubacterium limosum, 1 strain of Bifidobacterium adolescentis, 1 strain of Clostridium perfringens, 6 strains of Peptococcus variabilis, 4 strains of P. asaccharolyticus, 1 strain of P. aerogenes, 5 Strains'of Peptostreptococcus anaerobius, 4 strains of Peptostreptococcus intermedius and 4 strains of Gafficjia a naerobia) was examined.
The results obtained are mentioned below:
1. The antimicrobial activity against B.fragilis, B.thetaiotaomicron, B.vulgatus and B.distasoniswas superior in the order of V, I, III, II and IV. I was superior in antimicrobial activity to VI, VII and VIII.
2. The antimicrobial activity against P.variabilis was superior in the order of VII, V, I and VIII. The antimicrobial activity against P.asaccharolyticus was superior in the order of V, IV and VII.
3. I and V were most antibacterial against Ps.anaerobius. I and II indicated a high antibacterial activity against Ps.intermedius.
4. IV, VI, VII and VIII were more antibacterial against G. anaerobia than, I; II and III were.
5. I revealed MIC levels of less than 0.78-Eg/ml against B.praeacutus, E.limosum, B.adolescentis, P. aerogenes and C. perfringens, while most of these microbes revealed MIC levels of less than 0.2μg/ml.
6. F. russii was sensitive to 0.2μg/ml of I.F.varium and F.freundii were resistant to 100μg/ml of I, II and III.
7. I showed a good antibacterial activity against 16 anaerobes like B.fragilis, except, for F.varium and F.freundii. Antibacterial activity of I was comparable to that of V.
