Abstract
Clinical efficacy of CS-1170 in 13 children with acute infections was evaluated. The daily dosage was 20-40mg/kg in 4 cases, 50-70 mg/kg in 8 cases and 100 mg/kg in 1 case, with the period of administration ranging from 2 to 4 days in 9 cases and from 6 to 10 days in 4 cases. The drug was given intravenously, either by drip infusion or by injection. The result was excellent in 3 cases, good in 6 cases, fair in 1 case and poor in 1 case, with 2 cases excluded from the evaluation of efficacy: thus, the rate of response was 82%.
In 5 cases of acute respiratory tract infections, the results were excellent in 2 cases, good in 1 case and poor in 1 case, while 1 case of mycoplasma pneumonia was excluded from this determination.
In 5 cases of acute enteritis, excellent result was obtained in 1 case, good results in 3 cases and fair in 1 case. The drug had shown good results in a case of varicella plus impetigo, and in another case of Ritirsa's disease (dermatitis exfoliative neonatorum), but a case (fever of central origin) was excluded from this evaluation. All cases showed negative result in the cutaneous reaction test, however, a patient developed nettle rash 8 days after commencement of the drug administration.
No abnormality was found in the hematopoietic, liver and kidney functions of the patients.
