Abstract
Cefazolin (CEZ) concentration in the bone marrow of tibia was examined1, 2 and 3 hours after intramuscular injection of 1g.
CEZ concentration in the bone marrow of tibia 1 hour after injection was 59.9±10.31μg/ml. Ratio to serum was 101.7%.CEZ concentration in the bone marrow of tibia 2 hours after injection was 42.5±7.77μg/ml.Ratio to serum was 102.7%.CEZ concentration in the bone marrow of tibia 3 hours after injection was 33.9±7.75μg/ml.Ratio to serum was 102.7%.
Penetration capacity of CEZ into the bone marrow of tibia was excellent.
