Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Reduced Thymic Size and Numbers of Splenic CD4+ and CD8+ Cells in Artificially Reared Mouse Pups
Masako YAJIMAJunji HOSHIBAMasaki TERAHARATakaji YAJIMA
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2007 Volume 71 Issue 10 Pages 2420-2427

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Abstract
The effect of early nutrition on the development of the immune tissue and T cells of mouse pups was examined. Newborn mice were divided into three experimental groups: mother-reared (MR) pups, pups that were fed on a milk substitute from the first day (AR-0), and the third day (AR-2), using a hand-feeding system. The average thymic size of the AR-2 pups was respectively significantly larger and smaller than that of the AR-0 and MR pups. In contrast, the splenic sizes of the AR-0 and AR-2 pups were greater than that of the MR pups. The numbers of CD4+CD8 and CD4CD8+ cells in the spleen of the MR pups were significantly higher than those in the AR-0 pups. These results indicate that early nutrition affected the sizes of the thymus and spleen and the composition of CD4+CD8 or CD4CD8+ T cells in the spleen.
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© 2007 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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