STUDIES OF DIBEKACIN EYE-DROPS INTRAOCULAR PENETRATION

Abstract

Ocular tissue levels of dibekacin (DKB) were studied in rabbits after instillation of 0.3% DKB eye-drops five times every 5 minutes.
(1) In normal eyes, DKB levels were determined in all of the outer parts of eye and some of inner parts such as aqueous humor and vitreous body. Such levels were relatively higher than those of gentamicin.
(2) In cauterized eyes by NaOH tissue levels were several times higher than those obtained in normal eyes.
(3) Considering these results and MIC levels against both Gram-positive and Gram-negative bacteria such as Pseudomonas aeruginosa or Staphylococcus aureus, it is suggested that 0.3% DKB eye-drops will show effectiveness in clinical use.