Abstract
Clinical evaluation was made on cefoperazone (CPZ) and the following conclusions were obtained.
(1) Serum concentrations of the drug after a one-shot intravenous injection of 22.2mg/kg were 77mcg/ml (30 minutes), 50mcg/ml (1 hour) and 8.9mcg/ml (4hours) and T1/2 of serum concentration was 68.5 minutes.A 35-day-0ld female with obstructive jaundice associated with choledochal.cyst was given by a 30-minute drip infusion of 26.8mg/kg of the drug.Serum concentration was 90mcg/ml at the end of infusion, slowly declined thereafter, and was 47.5mcg/ml at 6hours.Its T1/2 was 395 minutes.A patient with pyelonephritis complicated with right hydronephrosis was similarly treated with 24.4mg/kg.T1/2 of serum concentration was not prolonged, i.e., 82.1minutes, but urinary recovery rate up to 6 hours was decreased to 15.9%.
(2) Five patients, including three with pyelonephritis (causative organism: K.pneumoniae 2 and P.aeruginosa 1) and each one patient with pneumonia (unknown) and with postoperative infection (S. faecalis), respectively, were treated with 66.7-96.8mg/kg/day of CPZ in 3 divided doses for 5-12 days either by one-shot intravenous or by 30-60-minute drip infusion.An overall efficacy rate was excellent in 3 and good in 2, and there was no failure.Causative organisms disappeared in all cases.
(3) Although one patient was excluded from the study because the diagnosis was supposed to be viral proumonia, all six patients who were given CPZ did not exhibit any adverse reactions except for mild eosinophilia in two instances.
(4) The foregoing results as well as the review of the literature clearly indicate the eHectiveness of CPZ in the treatment of bacterial infections in children.
