1981 Volume 34 Issue 12 Pages 1680-1690
Clinical efficacy of cefroxadine dry syrup, a new oral cephalosporin antibiotic, was evaluated in children, and the following results were obtained.
1. Three children were given a single oral dose of about 10 mg/kg of the drug when fasting, and its blood concentrations were determined. Blood concentrations were maximum at 30-60 minutes, i.e., 16.9-18.2 μg/ml, and markedly low at 4 hours.
2. Thirty-six patients with the following diseases were treated with 23.1-44.4 mg/kg/day of the drug in 3 to 4 divided doses; 21 patients with lacunar tonsillitis, 2 with tonsillitis, 1 with scarlet fever, 4 with bronchitis and tonsillitis, 2 with cystitis, 4 with pyelonephritis, 1 with impetigo and 1 with probable Mycoplasma pneumonia. An overall efficacy rate in 35 patients excluding the last mentioned case was 91.4%, i.e., excellent in 20, good in 12 and poor in 3, and an eradication rate of the causative organisms was 88.9%.
3. Adverse reactions noted were diarrhea in 1 patient, eruption and diarrhea in 1, transient neutropenia in 1, eosinophilia in 3 and an elevation of GOT and GPT in 1. None were significant.
4. Taste and flavor of the drug was considered to be well palatable to children.
5. Taking into consideration of the results of fundamental evaluation of the drug, cefroxadine dry syrup is considered to be a potent new antibiotic in children, and the recommended dose will be 10mg/kg 3 to 4 times a day.
