TRANSFER OF FOSFOMYCIN INTO CEREBROSPINAL FLUID

Abstract

After the fosfomycin(FOM) infusion, its levels in serum and cerebrospinal fluid (CSF) were repeatedly measured in 8 cases without meningitis.
1.The peak concentration of FOM in CSF was 15.5μg/ml with the average of 10.3μg/ml and was reached at 240 minutes with the average of 210 minutes after the infusion. The biological half life time of FOM in CSF was 2 to 6.5 hours.
2.The peak concentration in CSF was compared with it in serum. The average ratio was 4.3 per cent.Fitch area under the curve (AUC) of FOM concentration in CSF and serum was calculated and average of their ratio was 9.0 per cent.
3.In a case with middle cerebral artery aneurysm, FOM transferred into CSF with ease. The lowest diffusion into the CSF was shown in 2 cases of meningioma.In 3 cases of hypertensive intracerebral hemorrhage with intraventricular perforation, FOM moderately transfered into CSF.