1982 Volume 35 Issue 2 Pages 399-408
Experimental and clinical studies on ceftizoxime (CZX), a newoephalosporin derivative, were carried out and the following results were obtained.
1.The minimal inhibitory concentrations of CZX, cefazolin 4CEZ), cephalothin (CET), cefotiam (CTM) and cefmetazole (CMZ) against Gram-positive cocci (31 strains) and Gram-negative rods (169 strains) isolated from the patients with oral infections were determined.CZX, though somewhat less active against Gram-positive cocci than the other oephalosporins, was the most active of the antibiotics tested against Gram-negative rods.
2.The mean serum levels in 19 patients who received I g of CZX by intravenous drip infusion for 1 hour were as follows: 19.6μg/ml 30 minutes after the start of intravenous drip infusion, 52.2μg/ml after 1 hour, 25μg/ml after 1.5hours, 20.3μg/ml after 2 hours, 7.9μg/ml after 4 hours, 3.5μg/ml after 6 hours.The mean peak tissue levels of CZX after 1 g dose by intravenous drip infusion for I hour were14.3μg/g (n=5) in gingiva and 8.5μg/g (n=2) in bone marrow at the end of intravenous drip infusion.
3.CZX was administered to 17 patients with various infections in the oral surgical field at daily dose of1-2g for3-6 days.The therapeutic effect was as follows: ‘excellent’ in 6 cases, ‘good’ in 9, ‘fair’ in 1 and ‘poor’ in 1. The final rate of effectiveness was 88.2%.
No adverse reaction was observed except for 2 cases of slight elevation of S.GPT.
