CLINICAL EVALUATIONS OF TOBRAMYCIN IN TREATMENT OF CHRONIC COMPLICATED URINARY TRACT INFECTIONS BY INTRAVENOUS DRIP INFUSION ADMINISTRATION
1982 Volume 35 Issue 2 Pages 409-420
Details
1982 Volume 35 Issue 2 Pages 409-420
1. Clinical pharmacology
The pharmacological studies on tobramycin (TOB) were studied in clinical patients. The peak serum levels following intravenous drip infusion (i.v.d.) administration of TOB 60mg were4.62mcg/ml in 0.5 hour and 4.09 mcg/ml in 1 hour respectively which achieved at the discontinuance of the drug. In 1 case, the concentration in serum and urinary recovery were determined when 60 mg of TOB was given twice a day in i.v.d. at an interval of 5 hours. The peak serum level was 4.11mcg/ml at the first administration, and 4.96mcg/ml at the second.No significant accumulation of the drug was observed. The urinary recovery of TOB during0-11.5hours was44%.
2. Clinical results
Tobramycin was administered in a dose of 60-120mg once or twice a day by i.v.d.against18cases of chronic complicated UTI.The duration of treatment varied but generally 5 days.An overall excellent or moderate effect was seen in81%.
3. Clinical chemistry
The clinical abnormal values from laboratory tests of renal, hepatic function and peripheral hematology in patients treated with TOB were obsereved in 2 cases.In 1 case BUN increase (17.6→23mg/dl) and in the other GOT and GPT elevations (GOT 24.1→u→66.7u, GPT 26.2u→68.8u).The abnormal values, however, returned to normal within 2 weeks after the discontinuance of the drug.
4. Clinical tolerance
Adverse reactions were encountered in 2 cases.The 1 case yielded skin rash with itching in the second day after therapy.The other case complained of general itching with mild headache 2 days after starting therapy.In above cases TOB treatment was discontined, soon after appearing these symptoms.The complete recoVery was recognized within 2 days in each case.
5. Summary
Based on the clinical pharmacology and clinical studies, intravenous drip infusion administration of tobrarnycin can be given safely and effectively in treatment of chronic complicated UTI.
