1982 Volume 35 Issue 2 Pages 429-437
1. The dry syrup of MOM was administered orally to 17patients mainly with heart deseases at doses of 10mg/kg and 20mg/kg.In 17cases, the serum level was measured and in 4cases, the urinary excretion rate including the metabolites of MOM.
2. The mean maximal concentrations were 0.54mcg/ml at30minutes for the group of 10mg/kg treatment and 0.33mcg/ml at 1hour for the group of 20mg/kg treatment.The dose response was not observed obviously in both groups.
3. In each of the cases, the sum of excretion rates of metabolites in the 24-hour urine was about 1%.
4. MOM was administered clinically to 39cases with respiratory tract infections and the overall efficacy rate was 85%.
5. In this study, 5 strains of S.pyogenes were isolated and the eradication rate was60%.
6. Although severe side effects were not observed, gastrointestinal abnormalities like diarrhea and vomiting were seen in 3cases.
7. Any pediatric patient did not refuse taking.
