THIRTY-DAY SUBACUTE INTRAMUSCULAR TOXICITY STUDY AND THIRTY-DAY RECOVERY STUDY OF NETILMICIN IN BEAGLE DOGS

Abstract

The subacute toxicity of netilmicin (NTL), an aminoglycoside antibiotic, in Beagle dogs was compared with that of gentamicin (GM).NTL at dose levels of1.5, 6, 25and100mg/kg/day and GM at dose levels of6and 25mg/kg/day were given intramuscularly for30 days.Control dogs received physiological saline.After the termination of the administration period, 2 males and 2 females among 5 males and 5 females from each group* were retained for a30-day recovery period. (For the GM 25mg/kg/day group, 1male and1female were retained for the recovery test)