1982 Volume 35 Issue 2 Pages 614-629
Teratological study on netilmicin (NTL), a new aminoglycoside antibiotic, was carried out in Sprague-Dawley rats (Slc: SD).NTL was administered intramuscularly to female rats from day 7 to day 17 of gestation at the dosages of12.5, 25, 50and100mg/kg.
The decrease of food intake at the dosage of50mg/kg and more, and the resultant depression of maternal body weight gain at the dosage of100mg/kg were observed in dams receiving NTL.
The depression of fetal growth, such as body weight and ossification of the sternebrae and caudal vertebrae, were detected in the animals treated with50and100mg/kg of NTL.However, NTL failed to induce the external, visceral and skeletal anomalies in fetuses.
Also, NTL did not cause any significant changes in birth rate, s uckling rate, weaning rate, body weight, postnatal development, behavior and reproductive performance in F1.
These results suggest that NTL has no adverse effect on rat fetuses and F1 generation at the dosage of 25 mg/kg or less.
