Abstract
Micronomicin (MCR) is a new aminoglycoside antibiotic prod uced by Micromonospora sagamiensis var. nonreducans which was isolated from soil collected at Sagamihara by NARA et al. The purified antibiotic showed a close similarity to gentamicin C complex in physical and chemical properties.
The antibacterial activity of MCR is broad-spectrum and almo st equal to that of gentamicin C complex. MCR exhibits particularly high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc. and high activity against some Pseudomonas aeruginosa strains resistant to gentamicin C1a.
A study on the irritation by repeated intravenous injection in dogs was carrie d out for safety evaluation (Doses: 4, 10, 25, 63 mg/kg and 100 mg/kg). Bleeding, edema, vasculitis and perivasculitis were ob served at injection sites both in physiological saline-treated controls and MCR-treated groups. But irritation attributable to MCR was not observed at any dose.
