耳鼻咽喉科領域感染症に対するセフェム系抗生物質Cefbtiamの臨床的効果

馬場 駿吉; 和田 健二; 波多野 努; 木下 治二; 杉森 久一; 佐々木 亨; 宮野 和夫; 円山 宏洋; 滝本 勲; 稲福 繁; 野村 隆彦; 丸尾 猛; 山下 公一; 佐藤 喜一; 吉住 隆; 太田 文彦; 宮前 雅明; 米井 潔; 平野 実; 大久保 洋; 大久保 泰

doi:10.11553/antibiotics1968b.36.2693

CLINICAL EFFECT OF CEPHALOSPORIN DERIVATIVE CEFOTIAM IN THE FIELD OF OTORHINOLARYNGOLOGY

SHUNKICHI BABA, KENJI WADA, TSUTOMU HATANO, HARUJI KINOSHITA, HISAKAZU SUGIMORI, TOORU SASAKI, KAZUO MIYANO, HIROMI MARUYAMA, ISAO TAKIMOTO, SHIGERU INAFUKU, TAKAHIKO NOMURA, TAKESHI MARUO, KOICHI YAMASHITA, KIICHI SATO, TAKASHI YOSHIZUMI, FUMIHIKO OHTA, MASAAKI MIYAMAE, KIYOSHI YONEI, MINORU HIRANO, HIROSHI OHKUBO, TOORU OHKUBO

Author information

SHUNKICHI BABA
Department of Otorhinolaryngology, School of Medicine, Nagoya City University
KENJI WADA
Department of Otorhinolaryngology, School of Medicine, Nagoya City University
TSUTOMU HATANO
Department of Otorhinolaryngology, School of Medicine, Nagoya City University
HARUJI KINOSHITA
Department of Otorhinolaryngology, School of Medicine, Nagoya City University
HISAKAZU SUGIMORI
Department of Otorhinolaryngology, Sapporo National Hospital
TOORU SASAKI
Department of Otorhinolaryngology, Asahikawa City Hospital
KAZUO MIYANO
Department of Otorhinolaryngology, Aomori Prefectural Central Hospital
HIROMI MARUYAMA
Department of Otorhinolaryngology, Aomori Prefectural Central Hospital
ISAO TAKIMOTO
Department of Otorhinolaryngology, Aichi Medical School
SHIGERU INAFUKU
Department of Otorhinolaryngology, Aichi Medical School
TAKAHIKO NOMURA
Department of Otorhinolaryngology, Aichi Medical School
TAKESHI MARUO
Department of Otorhinolaryngology, Koseiren Showa Hospital
KOICHI YAMASHITA
Department of Otorhinolaryngology, Kanazawa Medical School
KIICHI SATO
Department of Otorhinolaryngology, Kanazawa Medical School
TAKASHI YOSHIZUMI
Department of Otorhinolaryngology, Kanazawa Medical School
FUMIHIKO OHTA
Department of Otorhinolaryngology, School of Medicine, Kinki University
MASAAKI MIYAMAE
Department of Otorhinolaryngology, School of Medicine, Kinki University
KIYOSHI YONEI
Department of Otorhinolaryngology, School of Medicine, Kinki University
MINORU HIRANO
Department of Otorhinolaryngology, School of Medicine, Kurume University
HIROSHI OHKUBO
Department of Otorhinolaryngology, School of Medicine, Kurume University
TOORU OHKUBO
Department of Otorhinolaryngology, School of Medicine, Kurume University

JOURNAL FREE ACCESS

1983 Volume 36 Issue 10 Pages 2693-2710

DOI https://doi.org/10.11553/antibiotics1968b.36.2693

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Abstract

CTM was administered at dose levels of 1 to 3g a day to 77 cases of otorhinolaryngological infections, and the following results were obtained:
1. The effect of the drug was determined in 75 cases. The responders were 3 out of 5 (60.0%) in acute suppurative otitis media, 4 out of 11 (36.4%) in chronic suppurative otitis media, 39 out of 43 (90.7%) in tonsillitis and peritonsillar abscess and 12 out of 16 (75.0%) in other diseases, a total of 58 out of 75 cases (77.3%).
2. The bacteriological effect of CTM was evaluated in 53 cases, and bacterial eradication wasd emonstrated in 41 cases (77.4%). Also, its antibacterial potency was 2 to 4 times superior in comparison to that of CEZ against isolated bacteria in which MICs were measurable.
3. Side effects which were neither severe nor specific were recognized in 3 out of 77 cases (3.9%). In the cases with abnormal laboratory values, none was determinable to be attributed to CTM.

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