Ampicillin坐剤 (KS-R1) の小児尿路感染症に対する臨床効果

本廣 孝; 田中 耕一; 古賀 達彦; 島田 康; 冨田 尚文; 阪田 保隆; 藤本 保; 西山 亨; 久田 直樹; 石本 耕治; 富永 薫; 山下 文雄; 永山 清高; 湯浅 洸; 田中 祥視; 津川 信; 荒牧 修一; 大山 幸徳; 吉永 陽三; 河野 信晴; 下飛田 喬; 武知 哲久; 岩井 直一; 佐々木 明; 種田 陽一; 溝口 文子; 中村 はるひ

doi:10.11553/antibiotics1968b.36.1959

CLINICAL EXPERIENCE WITH AMPICILLIN SUPPOSITORY (KS-R1) IN URINARY TRACT INFECTION OF CHILDREN

TAKASHI MOTOHIRO, KOICHI TANAKA, TATSUHIKO KOGA, YASUSHI SIMADA, NAOFUMI TOMITA, YASUTAKA SAKATA, TAMOTSU FUJIMOTO, TOHRU NISHIYAMA, NAOKI KUDA, KOJI ISHIMOTO, KAORU TOMINAGA, FUMIO YAMASHITA, KIYOTAKA NAGAYAMA, TAKESHI YUASA, YOSHIMI TANAKA, SHIN TSUGAWA, SYUICHI ARAMAKI, KOTOKU OHYAMA, YOHZOH YOSHINAGA, NOBUHARU KAWANO, TAKASHI SHIMOHIDA, TETSUHISA TAKECHI, NAOICHI IWAI, AKIRA SASAKI, YOICHI TANEDA, FUNKO MIZOGUCHI, HARUHI NAKAMURA

Author information

TAKASHI MOTOHIRO
Department of Pediatrics, School of Medicine, Kurume University
KOICHI TANAKA
Department of Pediatrics, School of Medicine, Kurume University
TATSUHIKO KOGA
Department of Pediatrics, School of Medicine, Kurume University
YASUSHI SIMADA
Department of Pediatrics, School of Medicine, Kurume University
NAOFUMI TOMITA
Department of Pediatrics, School of Medicine, Kurume University
YASUTAKA SAKATA
Department of Pediatrics, School of Medicine, Kurume University
TAMOTSU FUJIMOTO
Department of Pediatrics, School of Medicine, Kurume University
TOHRU NISHIYAMA
Department of Pediatrics, School of Medicine, Kurume University
NAOKI KUDA
Department of Pediatrics, School of Medicine, Kurume University
KOJI ISHIMOTO
Department of Pediatrics, School of Medicine, Kurume University
KAORU TOMINAGA
Department of Pediatrics, School of Medicine, Kurume University
FUMIO YAMASHITA
Department of Pediatrics, School of Medicine, Kurume University
KIYOTAKA NAGAYAMA
Department of Pediatrics, Iizuka Hospital
TAKESHI YUASA
Department of Pediatrics, Iizuka Hospital
YOSHIMI TANAKA
Department of Pediatrics, Iizuka Hospital
SHIN TSUGAWA
Department of Pediatrics, Iizuka Hospital
SYUICHI ARAMAKI
Department of Pediatrics, Iizuka Hospital
KOTOKU OHYAMA
Ohyama Pediatrics Clinic
YOHZOH YOSHINAGA
Yoshinaga Pediatrics Clinic
NOBUHARU KAWANO
Kawano Pediatrics Clinic
TAKASHI SHIMOHIDA
Shimohida Pediatrics Clinic
TETSUHISA TAKECHI
Department of Pediatrics, Yame Municipal Hospital
NAOICHI IWAI
Department of Pediatrics, Meitetsu Hospital
AKIRA SASAKI
Department of Pediatrics, Meitetsu Hospital
YOICHI TANEDA
Department of Pediatrics, Meitetsu Hospital
FUNKO MIZOGUCHI
Department of Pediatrics, Meitetsu Hospital
HARUHI NAKAMURA
Department of Pediatrics, Meitetsu Hospital

JOURNAL FREE ACCESS

1983 Volume 36 Issue 7 Pages 1959-1972

DOI https://doi.org/10.11553/antibiotics1968b.36.1959

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Abstract

1. Clinical effects of ampicillin suppository (KS-R1) were examined in 24 children (11 male and 13 female) aged fkrom 5 months to 7 years 5 months with urinary tract infection. KS-R1 was rectally given to the patients at doses of average 45.6mg/kg/day divided into 3 to 4 times for average 8 days.
2. Clinical effectiveness was 95.8%.
3. Bacteriologically, the eradication of isolated organisms was observed in 10 (71.4%) out of 14 cases, the decrease in 3 (21.4%) and the persistence in 1 (7.1%).
4. The discharge of suppository within 5 minutes after insertion was observed in 8.7% of patients without diarrhea and in 6.9% of patients with diarrhea.
5. The evacuation rate of the bowels within 10 minutes after insertion was observed in 5.9% of patients without diarrhea and in 41.9% of patients with diarrhea. It was suggested that the administration of KS-R1 to childish patients with diarrhea should be careful.
6. As to the side effects, diarrhea was observed in 2 cases (7.1%) and the elevation of GPT and GOT in 1 case (3.6%).

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