Abstract
Fundamental and clinical studies were performed oh cefpiramide (CPM), a new cephem antibiotic, with the following results.
1. Following a single intravenous administration of 1.0g dose of CPM, the average serum level of CPM was 129.5 μg/ml after 1 hour and the half-life. in β-phase was about 5.0 hours.
The transfer of CPM to the internal genital organs was found to be good.
The transfer of CPM to retroperitoneal fluid was moderate.
2. In clinical trial, CPM was given to 9 patients with obstetrical and gynecological infection. Efficacy was excellent in 1 case and good in 6 cases (effectiveness rate: 77.8%).
3. No side effects were observed. In laboratory findings, a mild elevation of S-GOT was noted in 1 case.
