POSTOPERATIVE EVALUATION OF RENAL FUNCTION FROM THE ASPECT OF URINARY CONCENTRATION

CEFMETAZOLE IN INFANTS AND CHILDREN WITH VESICOURETERAL REFLUX AND HYDRONEPHROSIS PART I

Abstract

The urinary excretion of cefmetazole (CMZ) which was administered intravenously from the both kidneys (affected side and normal side) was studied separately after surgery in 11 infants and children (10 cases of vesicoureteral reflux (VUR) and 1 case of hydronephrosis due to pelviureteric obstruction). In kidneys with VUR of grade IIb to III degree, urinary concentration of CMZ showed rather higher than that we expected from their creatinine clearance. On the contrary in kidneys with VUR of grade IV degree and hydronephrosis, urinary concentration of CMZ showed rather lower compared to their creatinine clearance.