Abstract
Transfer of cefmenoxime (CMX) into the burn blister fluids was studied in 10 burned patients with 2 administrated doses (25, 50mg/kg). CMX concentrations in serum and burn blister fluid after 1 hour intravenous drip infusion were measured using Proteus mirabilis ATCC 21100 as the test organism grown in the DST agar medium.
In the case of CMX 25mg/kg dose, the peak serum concentration was observed 61.5μg/ml at 1 hour, while the peak burn blister fluid concentration was observed 15.2μg/ml at 2 hours. Pharmacokinetic parameters of serum concentration calculated were 1.02 hours as half-life (β) and 0.42L/kg as distribution volume, respectively.
In the case of CMX 50mg/kg dose, the peak serum concentration was observed 122.0μg/ml at 1 hour and the peak burn blister fluid concentration was observed 40.8μg/ml at 2 hours. Pharmacokinetic parameters of serum concentration calculated were 1.27 hours as half-life (β) and 0.55L/kg as distribution volume.
From this study, the dose dependency between 25mg/kg dose and 50mg/kg dose in serum and in burn blister fluid is recognized.
