A STUDY ON TRANSFERENCE OF CEFMINOX INTO INTRAPELVIC TISSUES

Abstract

Intravenous administrations of cefminox (CMNX, MT-141) 1g as both single shot injection and drip infusion were absorbed rapidly. CMNX showed good transference into intrapelvic organs such as uterus, oviduct and ovary, with the tissue/serum ratios of 37.6% for myometrium, 35.1% for endometrium, 41.4% for cervix uteri, 49.5% for portio vaginalis, 54.3% for ovary and 59.7% for oviduct.
From these results, usefulness of CMNX in the field of obstetrics and gynecology was confirmed.