1986 Volume 39 Issue 7 Pages 1693-1700
Nine pediatric patients with moderate or severe bacterial infections (3 septicemia or bacteremia, 2 pyelitis, 2 tonsillitis, 1 pneumonia and 1 pyothorax) in hospital were treated with MK-0787/MK-0791. The drug was administered intravenously by 30 or 60 minutes drip infusion in 3 or 4 divided doses totalling 24mg/24mg-70.2mg/70.2mg per kg/day. Clinical effectiveness were excellent in 4 cases, good in 2 cases, poor in 2 cases and not evaluated in 1 case. The overall efficacy rate was 75%.
A slight decrease of WBC was observed in 1 case.
It was concluded that MK-0787/MK-0791 was a useful antibiotic for the treatment of infections in pediatric practices.
Pharmacokinetics of intravenously administered MK-0787/MK-0791 was studied in 2 other cases.
The MK-0787/MK-0791 was administered intravenously by 30 or 60 minutes drip infusion to 2 cases at a dose of 10mg/10mg/kg. The mean half-life (T 1/2) of MK-0787 was 1.03 hours and MK-0791, 0.69 hour. The mean urinary recovery rate of MK-0787 within 6.5-7 hours after administration was 62.5% and MK-0791, 76.7%.
