A CLINICAL STUDY ON IMIPENEM/CILASTATIN SODIUM IN THE FIELD OF PEDIATRICS
1986 Volume 39 Issue 7 Pages 1701-1707
Details
1986 Volume 39 Issue 7 Pages 1701-1707
A clinical study on imipenem/cilastatin sodium (MK-0787/MK-0791) was carried out and the following results were obtained.
1. MK-0787/MK-0791 was used for treatment of a total of 33 patients and clinical effectiveness, bacteriological efficacy and adverse reactions were evaluated.
2. The clinical effects were excellent in 1 case, good in 21 cases and fair in 2 cases in a total of 24 cases with respiratory tract infections, were excellent in 5 cases and good in 1 case in a total of 6 cases with urinary tract infections, and were good in 2 cases and fair in 1 case in a total of 3 cases with gastroenteritis.
3. Causative organisms isolated from 11 patients were 1 strain of Gram-positive cocci and 10 strains of Gram-negative bacilli. Ten out of 11 strains were eradicated for an eradication rate of 91%. The clinical efficacy was confirmed in 11 cases for an efficacy rate of 100%. The bacteriological study has shown that MK-0787/MK-0791 has a strong antimicrobial activity.
4. No side effects were observed. There was only one abnormal laboratory finding, i.e., a case of eosinophilia.
