1986 Volume 39 Issue 9 Pages 2285-2300
A subacute toxicity study on T-2588 was carried out in juvenile rats (6 days-old 48 males and 48 females) by oral administrations at dose levels of 250, 500 and 1,000mg/kg/day for 1 month.
The results obtained were summarized below.
1. During the study, there were no clinical signs considered to be related to the treatment. There were no T-2588-related abnormalities in urinalysis, hematological examinations, biochemical examinations and ophthalmological examinations.
2. Slight increases in relative liver and kidney weights were observed in the 1,000mg/kg-treated group and slight increases in relative kidney weight were detected in the 500mg/kg-treated female group. Histologically, however, T-2588-related abnormality was not observed.
3. The maximum safety dose of T-2588 was estimated to be 250mg/kg/day.
4. In addition to the above examinations, male reproductive performance was examined in the group administered with a dose level of 1,000mg/kg/day. No adverse effects were observed in male fertility and F1 generation.
