1986 Volume 39 Issue 9 Pages 2301-2306
A study on disulfiram-like reaction of T-2588 was carried out using Sprague-Dawley male rats. A 500mg/kg/day dose of T-2588 was given orally to 14 male rats once daily for 7 days. Disulfiram (200mg/kg/ day×3 days, p. o.), cephalexin (CEX)(500mg/kg/day×7 days, p. o.) and cefmetazole (CMZ)(500mg/kg/day×7 days, i. v.) were used as the positive control and 2 comparative controls, respectively.
The results obtained were summarized below.
1. Each parameter (aldehyde dehydrogenase activity and the blood aldehyde level) in the disulfiram-like reaction was not affected by the T-2588 administration.
2. A marked inhibition of aldehyde dehydrogenase activity (low-Km ALDH, Enzyme I) and a significant increase of the blood aldehyde level were observed in the rats receiving disulfiram.
3. No drug-related disulfiram-like reaction was induced in the male rats receiving CEX, while alterations similar to the disulfiram action were recognized in rats receiving CMZ.
