PHARMACOKINETIC STUDIES ON CEFMENOXIME

DISTRIBUTIONS INTO UTERUS AND INTRAPELVIC GENITAL ORGANS

Abstract

Concentrations of cefmenoxime (CMX) in peripheral venous serum, uterus and intrapelvic genital organs were determined by bioassay. The obtained results are summarized below.
1. When 1g of CMX was administed by an intravenous injection, peak concentrations in various tissues of female genital organs were as follow: 17.4 and 46.8μg/g in ovary and oviduct, respectively, and from 28.2 to 43.8μg/g in other genital organs.
2. These concentrations of CMX were maintained at higher level than minimal inhibitory concentrations against E. coli, Bacteroides and other organisms.
3. In these studies, CMX showed a satisfactory clinical efficacy and a potent antibacteriological effect in the treatment of infections in the field of obstetrics and gynecology.