1986 Volume 39 Issue 9 Pages 2395-2398
Seven neonates and young infants were treated with cefotiam (CTM) in doses ranging from 8-25.6mg/kg every 6 to 24 hours for 1 to 14 days, and the clinical efficacy and side effects were evaluated. Among 5 infants with bacterial infections including bacteremia, perianal abscess, pneumonia, urinary tract infection and probable sepsis and meningitis, clinical responses were excellent in 1 and good in 4 patients. In the 7 patients, no side effect attributable to CTM was observed.
Serum concentrations of CTM were measured in 5 patients administered with 10 to 20mg/kg of CTM by bolus intravenous injection. Peak serum concentrations of 21.9 to 38.0μg/ml were noted in samples taken at 15 minutes after injection. Serum half-lives of the drug were 2.35 hours in 2 day-old neonate, 0.72 to 0.85 hours in 3 infants of 25 to 37 days, and 8.46 hours in an 18 day-old neonate with renal insufficiency.
