Abstract
ased on the results of a study on pulmonary tissue uptake of flomoxef (FMOX), a new antibiotic agent, in 45 patients undergoing thoracotomy, the following conclusions were drawn:
1. Immediately preoperative 1 hour-drug infusion of 1g FMOX led to maximum serum concentration (averaging 42.4 μg/ml) 1 hour later, with a half-life of its β phase of 1.26 hours.
2. Normal lung (alveolar) tissue concentration was Cmax 17.98μg/g with its ratios to serum peak value being 31.8, 27.1, 22.2, 9.4, 5.9 and 5.0% at 1, 2, 3, 4, 5 and 6 hours later, respectively.
3. Bronchiolar tissue concentration was Cmax 31.91μg/g, with its ratios to serum peak value being 27.8, 19.3 and 10.1% at 2, 3 and 4 hours later, respectively, indicating its good bronchiolar intra-tissue transition.
The above results suggested the usefulness of FMOX for both the treatment of respiratory infections and the prevention of postoperative infections.
