The Hydrophobicity in a Chemically Modified Side-Chain of Cysteine Residues of Thanatin Is Related to Antimicrobial Activity against Micrococcus luteus

Yoshitake ORIKASA; Kenta ICHINOHE; Junki SAITO; Shigeki HASHIMOTO; Ken’ichiro MATSUMOTO; Toshihiko OOI; Seiichi TAGUCHI

doi:10.1271/bbb.90183

This article has now been updated. Please use the final version.

The Hydrophobicity in a Chemically Modified Side-Chain of Cysteine Residues of Thanatin Is Related to Antimicrobial Activity against Micrococcus luteus

Yoshitake ORIKASA, Kenta ICHINOHE, Junki SAITO, Shigeki HASHIMOTO, Ken’ichiro MATSUMOTO, Toshihiko OOI, Seiichi TAGUCHI

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Keywords: antimicrobial peptide, thanatin, chemical modification

JOURNAL FREE ACCESS Advance online publication

Article ID: 90183

DOI https://doi.org/10.1271/bbb.90183

The final version of this article is now available: Vol. 73 (2009) , No. 7 p.1683

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Abstract

The chemically modified thanatin with the methyl group (CH₃), ethyl group (C₂H₅), and normal-octyl group (C₈H₁₇) at the side-chain of cysteine residues was synthesized. The octyl group modified form exhibited 8-fold higher antimicrobial activity against Micrococcus luteus than wild type thanatin. It was found that there was an equilateral correlation between antimicrobial activity and side-chain hydrophobicity at the cysteine residues in thanatin.

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