Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451

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The Hydrophobicity in a Chemically Modified Side-Chain of Cysteine Residues of Thanatin Is Related to Antimicrobial Activity against Micrococcus luteus
Yoshitake ORIKASAKenta ICHINOHEJunki SAITOShigeki HASHIMOTOKen’ichiro MATSUMOTOToshihiko OOISeiichi TAGUCHI
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JOURNAL FREE ACCESS Advance online publication

Article ID: 90183

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Abstract
The chemically modified thanatin with the methyl group (CH3), ethyl group (C2H5), and normal-octyl group (C8H17) at the side-chain of cysteine residues was synthesized. The octyl group modified form exhibited 8-fold higher antimicrobial activity against Micrococcus luteus than wild type thanatin. It was found that there was an equilateral correlation between antimicrobial activity and side-chain hydrophobicity at the cysteine residues in thanatin.
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