Article ID: 90183
The chemically modified thanatin with the methyl group (CH3), ethyl group (C2H5), and normal-octyl group (C8H17) at the side-chain of cysteine residues was synthesized. The octyl group modified form exhibited 8-fold higher antimicrobial activity against Micrococcus luteus than wild type thanatin. It was found that there was an equilateral correlation between antimicrobial activity and side-chain hydrophobicity at the cysteine residues in thanatin.
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