Abstract
A new injectable cephem antibiotic, cefpirome (CPR), was evaluated clinically in children. CPR was effective in all the 17 evaluable cases with acute bacterial infections including 1 case of purulent meningitis due to Haemophilus influenzae type b. Diarrhea and elevation of serum GOT and GPT were associated with CPR therapy in 2 young infants, although they were mild and transient.
The plasma T1/2 β of CPR was 1.17±0.22 hour safter bolus inlection and mostly excreted in 6 to 8 hours into urine of children with normal renal functions. The data indicate that CPR is safe and efnective, when used in children with susceptible bacterial infbctions.
