STUDY ON FLOMOXEF IN THE PERINATAL PERIOD

Abstract

The placental passage and the the therapeutic efficacy of flomoxef (FMOX, 6315-S) were studied in patients in the perinatal period. A summary of the obtained results is as follows:
1. Concentrations of FMOX in maternal serum, umbilical cord serum and amniotic fluid obtained upon one-shot intravenous injections to 12 patients were compared with those obtained upon 1 hour drip infusions to 9 patients. It was found that the former means of administration gave higher concentrations that the latter.
2. Concentrations of FMOX in maternal serum, umbilical cord serum and amniotic fiuid at 1 to 6 hours after administration through either method were all higher than MIC80's of recognized bacteria.
3. Clincal emcacies were evaluated in 10 patients with puerperal intrauterine infection, 7 patients with endometritis, 2 patients with pyeronephritis and 1 patient each with endocervicitis, amniotic fluid infection, mastitis and perineal wound infection. Clinical ethcacies were excellent in 5 patients (2L7%), good in 17 patients (73.9%) and poor in 1 patient (4.4%), thus the overall efficacy rate was 95.7%.
4. Eradication of causative bacteria were obtained in all 8 cases tested, hence the eradication rate was 100%.
5. Mild diarrhea in 1 patient was the only side effect observed. No abnormal clinical laboratory test results were fbund in any patients.