The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
A STUDY ON NEPHROTOXICITY OF ARBEKACIN AND VANCOMYCIN IN RATS
TETSUTAROU NIIZATO, MASATOSHI OHNISHI, SHOJI NISHIYAMA, HIROYASU ASAOKA, ATSUSHI SAITO
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1994 Volume 47 Issue 6 Pages 664-675

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Abstract

Nephrotoxicities of arbekacin (ABK) and/or vancomycin (VCM) were examined by administrating rats intravenously with single doses or 10 times repeated daily doses. ABK was found less toxic to kidney than VCM, and the toxicity was strengthened by combined treatment with VCM and ABK. Fosfomycin decreased the nephrotoxicity when added to the single or combined treatment with ABK and VCM.

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The Journal of Antibiotics, Series B

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